The Genetics of Heart & Vascular Disease

Genetics of Heart & Vascular Disease

The Genetics of Heart & Vascular Disease

Francis Marion Hotel, Charleston, SC

10/6/2017 - 10/7/2017


This 1 ½ day CME course is to have experts in the field of cardiovascular genetics detail the important role of genetics, genomics, and pharmacogenetics in the diagnosis, risk stratification, and treatment of diseases affecting the heart and the blood vessels.

Topics covered will include, Genetics/Genomics 101, pharmacogenetics, gene risk scores, genetic purgatory, the molecular autopsy, and the diagnostic, prognostic, & therapeutic implications of genetic testing for patients with congenital heart disease, long QT syndrome and the other channelopathies, hypertrophic cardiomyopathy and the other cardiomyopathies, coronary heart disease, hyperlipidemias, heart failure, pulmonary hypertension, and the aortopathies.

Unique Features:  Audience response system to enhance immediate feedback.  Easy access to faculty members.  One-on-one interaction.  Efforts will be made to introduce the clinical applications using new technology, however, there is no hands-on experience provided.  Self-assessment questions to gauge outcome.  

Upon conclusion of this program, participants should be able to:

  • Summarize the probabilistic nature of genetic testing and develop a strategy to manage the variant of uncertain significance (VUS) test results
  • Identify the impact of genetic testing in the diagnosis and pathophysiology of the heritable cardiomyopathies, channelopathies, and aortopathies
  • Determine the role of genetic testing children and adults with congenital heart disease
  • Define genetic markers of atherosclerosis and their role in risk stratification of coronary heart disease
  • Identify the genetic basis of heritable causes of the hyperlipidemias and implications for prevention and familial screening
  • Define the role of inheritance in cardiovascular drug response and to utilize genetics to minimize adverse events and maximize drug efficacy

This course is intended for pediatric and adult cardiologists, internists, primary care providers, and nurse practitioners with special interest in the management of patients with CVD, pediatric and adult cardiology trainees, and genetic counselors with an interest in cardiology. 


Friday, October 6, 2017

Day 1 - Session I - Genetics/Genomics 101 - Increasing the Cardio-Genetics IQ of Practicing Cardiologists/NPs/Trainees/GCs
Dr. Michael J. Ackerman, presiding

7:15 a.m.

Continental Breakfast - Prefunction Carolina Ballroom, Mezzanine Level
7:45 a.m. Introduction and Welcome
Michael J. Ackerman, M.D., Ph.D
8:00 a.m. Genetics & Genetic Testing 101: How Do You Spell D-N-A?
Michael J. Ackerman, M.D., Ph.D
8:30 a.m. Sanger, Next Gen, and WGS - Does the Technique Matter?
Linnea M. Baudhuin, Ph.D.
8:50 a.m. Polyphen, SIFT, CONDEL, PARALOGUES: This Is Greek to Me?
Johan (Martijn) M. Bos, M.D., Ph.D.
9:10 a.m. Genetic Purgatory: Exposing the Variant of Uncertain Significance (VUS) Issue
Michael J. Ackerman, M.D., Ph.D.
9:40 a.m. Panel Discussion
Drs. Baudhuin and Bos; Dr. Ackerman, moderator
10:00 a.m. Refreshment Break


Day 1 - Session II - Pharmacogenetics and Complex Disease Genetics 101 - Increasing the Cardio-Genetics IQ of Practicing Cardiologists/NPs, Trainees/GCs
Dr. Naveen L. Pereira, presiding

10:20 a.m. Understanding Pharmacogenetics 101: CYPs, et. al.
Naveen L. Pereira, M.D.
10:50 a.m. Interpreting the Genetic Testing Report: From SNPs/Risk Scores to Gene Panels/WES
Iftikhar J. Kullo. M.D.
11:20 a.m. The GCATs and the ABCs of Genetic Counseling
Teresa M. Kruisselbrink, M.S., CGC
11:50 a.m. Panel Discussion
Dr. Kullo and Ms. Kruisselbrink; Dr. Pereira, moderator
12:15 p.m. Lunch - Prefunction Carolina Ballroom


Day 1 - Session III - Sudden Death Predisposing Channelopathies and Cardiomyopathies: Diagnostic, Prognostic, & Therapeutic Implications of Genetic Testing For ...
Dr. Michael J. Ackerman, presiding

1:30 p.m. Long QT Syndrome
Michael J. Ackerman, M.D., Ph.D.
2:00 p.m. Brugada Syndrome and CPVT
Arthur A.M. Wilde, M.D., Ph.D.
2:30 p.m. Hypertrophic Cardiomyopathy
Michael J. Ackerman, M.D., Ph.D.
3:00 p.m. Refreshment Break
3:20 p.m. Arrhythmogenic Cardiomyopathy
Arthur A.M. Wilde, M.D., Ph.D.
3:50 p.m. DCM, RCM, and LVNC
Johan (Martijn) M. Bos, M.D., Ph.D.
4:20 p.m. Sudden Death in the Young: State of the Molecular Autopsy
Michael J. Ackerman, M.D., Ph.D.
4:50 p.m. Panel Discussion
Drs. Wilde and Bos; Dr. Ackerman, moderator
5:20 p.m. -
6:30 p.m.
OPTIONAL - Special Evening Session - Expert Analysis of Genetic and Pharmacogenetic Test Reports from Your Patients
Drs. Ackerman, Kullo, Pereira, Wilde, and Ms. Kruisselbrink


Saturday, October 7, 2017


Day 2 - Session IV - Genetics and Pharmacogenetics of ...
Dr. Iftikhar J. Kullo, Presiding

7:30 a.m. Continental Breakfast - Prefunction Carolina Ballroom, Mezzanine Level
8:00 a.m. Congenital Heart Disease
David R. Deyle, M.D.
8:30 a.m. Familial Hyperlipidemias
Iftikhar J. Kullo, M.D.
9:00 a.m. Heart Failure
Naveen L. Pereira, M.D.
9:30 a.m. Panel Discussion
Drs. Bonnichsen and Pereira; Dr. Kullo, moderator
10:00 a.m. Refreshment Break
10:20 a.m. Coronary Heart Disease
Iftikhar J. Kullo, M.D.
10:50 a.m. Pulmonary Hypertension
Naveen L. Pereira, M.D.
11:05 a.m.  Marfan Syndrome and Other Aortopathies
David R. Deyle, M.D.
11:35 a.m. Amyloidosis
Naveen L. Pereira, M.D.
11:50 a.m. Panel Discussion
Drs. Pereira and Deyle; Dr. Kullo, moderator
12:15 p.m. Conclusion
Michael J. Ackerman, M.D., Ph.D.



Michael J. Ackerman, M.D., Ph.D.
Naveen Pereira, M.D.
Iftikhar J. Kullo, M.D.

Linnea M. Baudhuin, Ph.D.
Johan (Martijn) M. Bos, M.D., Ph.D.
David R. Deyle, M.D.
Teresa M. Kruisselbrink, M.S., CGC

Arthur A.M. Wilde, M.D., Ph.D


Mayo Clinic College of Medicine and Science is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Mayo Clinic College of Medicine and Science designates this live activity for a maximum of 12.5 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 12.5 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Participation information will be shared with ABIM through PARS.

*ABIM MOC is only eligible for Physicians boarded by the American Board of Internal Medicine

Other Health Care Professionals
A certificate of attendance will be provided to other health care professionals for requesting credits in accordance with state nursing boards, specialty societies, or other professional associations.

Attendees should ensure in advance that their credentialing or licensing organization accepts AMA PRA Category 1 CreditsTM from the sponsor of this activity.


MD, PhD, DO, PharmD  $575
Trainees, RN, PA, NP, GC  $450


If you cancel your participation in this course, your registration fee, less a $75 administration fee, will be refunded when written notification is received by Mayo Clinic CV CME before, Friday, September 22, 2017 (email: No refunds will be made on or after Friday, September 22, 2017. Canceled registrations are non-transferable.

Mayo Clinic CV CME reserves the right to cancel or postpone any course due to unforeseen circumstances. In the unlikely event Mayo Clinic CV CME must cancel or postpone this course, Mayo Clinic CV CME will refund the registration fee, but is not responsible for any related costs, charges, or expenses to participants, including fees assessed by airline/travel/lodging agencies.

This course is intended to be a live learning experience. If you do not attend this course on-site as a live learner, you will not be allowed access to the materials/lectures during or after the course. No refunds will be given for no-show registrants.


The Francis Marion Hotel opened in 1924 as the largest and grandest in the Carolinas.  Today, the hotel offers all of the traditional services including doorman, bell service, concierge, valet parking, room service, wireless internet, business center, newsstand, gift shop, spa, starbucks, and fitness center as well as The Swamp Fox Restaurant/Bar, a Charleston restaurant known for its artfully prepared dishes using local farm fresh ingredients or simply relax with jazz piano music.

Francis Marion Hotel
387 King Street
Charleston, SC 29403

To secure your room at the Francis Marion Hotel, please call 843-722-0600 or 877-756-2121 and state that you will be attending the Mayo Clinic Conference.  The room rate is $259 (single/double).  The room block is scheduled to be held until Friday, September 15, 2017 but may be sold out before this date.  Therefore, we advise you to register for the program and reserve your lodging as soon as possible. 

On-line Booking:

Check-in time is 4:00 p.m.
Check-out time is 12:00 p.m.

Parking at the Hotel
Self-parking $17 per day/Valet Parking $22 per day

For further information regarding the area and its attractions, please refer to:

Mayo Clinic Department of Cardiovascular Medicine is not responsible for expenses incurred by an individual who is not confirmed and for whom space is not available at the meeting.  Costs incurred by the registrant such as airline or hotel fees or penalties are the responsibility of the registrant.

Lodging and travel arrangements are the sole responsibility of the individual registrant.

Commercial Support

At the time of posting, a complete listing of commercial supports (financial or in-kind) was not available. Appropriate acknowledgement will be given to all supporters at the time of the meeting.

This course offers the opportunity for commercial companies to interact with health care providers and highlight their products and services. If you are interested in exhibit space during this course, please contact Sheila Fick. Exhibits will be available for viewing at all scheduled breaks.

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