Venous thromboembolism is a major source of morbidity and mortality in the United States, with more than 300,000 new cases occurring each year. In recent years, a number of variables have been established to prevent and improve early identification of VTE including: heightened awareness, identification of patients at risk, aggressive VTE prophylaxis campaigns, improved diagnostic methods and treatment strategies. Despite these accomplishments, the incidence of VTE has increased at a rate of 3% annually. Hospital associated VTE accounts for 25% of the incidence of VTE. Most of the events in this population occur following hospital discharge. This lecture will provide the learner with a concise overview of the VTE prophylaxis with a framework for implementation of VTE prophylaxis amidst a busy daily hospital practice.