George M. Gura Symposium: Advancing Tissue Engineered Valves to Clinical Practice

Advancing Tissue Engineered Valves to Clinical Practice

George M. Gura Symposium: Advancing Tissue Engineered Valves to Clinical Practice

Mayo Clinic - Phillips Hall, Siebens Building, Rochester, MN


Course Overview

This symposium is a unique opportunity to bring leading investigators in the area of biological heart valve development together to discuss progress in the field and the future for valve regeneration.

Program Highlights
• Discuss Current Challenges With Aortic Valve Replacements
• Recognize Development of Alternative Valve Technologies
• Discuss Valve Engineering: Research for Translation

This program is intended for cardiologists, cardiothoracic surgeons, interventionalists, physicians, anesthesiologists, engineers, basic researchers, and other health care professionals interested in advancing valvular heart disease.


Amir Lerman, M.D.
Mayo Clinic
Department of Cardiovascular Medicine

Melissa D. Young, Ph.D.
Mayo Clinic
Department of Cardiovascular Medicine

M. Dragomir Daescu, Ph.D
Joseph A. Dearani, M.D.
Leigh G. Griffiths, Ph.D.
Ashwani Khurana, Ph.D.
Joseph J. Maleszewski, M.D.
Jordan D. Miller, Ph.D.
Charanjit S. Rihal, M.D.
Walter R. Wilson, M.D.

Frank Baaijens, Ph.D.
University of Technology, Eindhoven 

Jonathan T. Butcher, Ph.D.
Cornell University, Biomedical Engineering.

Ian M.C. Dixon, Ph.D.
University of Manitoba, Canada

Simon P. Hoerstrup, M.D., Ph.D.
University of Zurich, Switzerland

Timothy McGloughlin, Ph.D.
Khalifa University, UAE

Michel Puceat, Ph.D.
Aix-Marseille University, France

Michael Sacks, Ph.D.
University of Texas at Austin

Robert D. Simari, M.D.
University of Kansas School of Medicine

Robert Tranquillo, Ph.D.
University of Minnesota

Mohamad Yaman, M.D.
Chief Medical Officer, Tawam Hospital


Sunday, October 1, 2017
Phillips Hall, Siebens Building, Street Level

8:15 a.m. Registration and Continental Breakfast
8:45 a.m. Welcome to Mayo Clinic
Mohamad Yaman, M.D.; Charanjit S. Rihal, M.D.
8:50 a.m. Program Overview
Amir Lerman, M.D.

SESSION 1: Current Challenges With Aortic Valve Replacements
Moderators: Charanjit S. Rihal, M.D.; Walter R. Wilson, M.D.

9:00 a.m. The Structural Basis of Aortic Valve Disease
Joseph J. Maleszewski, M.D.
9:15 a.m. Current Limitations to Surgical Treatment of Aortic Valve Disease
Joseph A. Dearani, M.D.
9:30 a.m. TAVR Limitations and Challenges
Charanjit S. Rihal, M.D.
9:45 a.m. Endocardial Cell Heterogeneity at the Origin of the Valvular Cell Clones and Identification of a Novel Gene Involved in Valve Development and Disease
Michael Puceat, Ph.D.
10:15 a.m. Question and Answer
Drs. Dearani and Rihal

SESSION 2: Development of Alternative Valve Technologies
Moderators: Robert D. Simari, M.D.; Mohamad Yaman, M.D.

10:30 a.m. Valves Made From Engineered Tissue Tubes
Robert Tranquillo, Ph.D.
11:00 a.m. Biocompatibility of Xenogeneic Biomaterials in Valvular Bioengineering
Leigh G. Griffiths, Ph.D.
11:30 a.m. Bioprinting in Valvular Bioengineering
Jonathan T. Butcher, Ph.D.
12:00 p.m. Synthetic Scaffolds in Valvular Bioengineering
Simon Hoerstrup, M.D., Ph.D.
12:30 p.m. Lunch - Landow Atrium

SESSION 3: Valve Engineering: Research for Translation
Moderators: Amir Lerman, M.D.; M. Dragomir Daescu, Ph.D.

1:30 p.m. Recellularization
Ian M.C. Dixon, Ph.D.
2:00 p.m. Biocompatibility for Valvular Bioengineering
Timothy McGloughlin, Ph.D.
2:30 p.m. Structural and Mechanical Requirements for Bioengineered Heart Valves
Michael Sacks, Ph.D.
3:00 p.m. Refreshment Break
3:15 p.m. Clinical Trials
Jordan D. Miller, Ph.D.
3:45 p.m. In Situ Tissue Engineering of Heart Valves
Frank Baaijens, Ph.D.
4:00 p.m. Panel Discussion
Drs. Dixon, McGloughlin, Sacks, Miller, and Baaijens
4:30 p.m. Conclusion and Adjourn
Amir Lerman, M.D.



Guest rooms have been reserved for attendees and their guests with special course rates at each of the Rochester Marriott Hotel. In order to receive the special rate, reservations must be made before the room block is filled or before the expiration date of September 8, 2017, whichever comes first. Reservations will be taken following this date based on space and rate availability. Please identify yourself as a participant of the Biological Valve Symposium when making your reservation.

Rochester Marriott Hotel
Group Rate - $139
Phone Reservations: 877-623-7775
Online Reservations

Travel Info

Mayo Clinic is located in downtown Rochester, Minn. Hotels, restaurants and shops are within easy walking distance. Many of these facilities are connected to clinic buildings by pedestrian walkways, called subways and skyways.

Link to Directions and Map

Parking is available in the following areas:
• Damon Parking Ramp, 15 Third Avenue S.W. and First Street S.W.
• Graham Parking Ramp, 121 Third Avenue N.W., between First and Second streets N.W.

Rochester is 10 miles north of Interstate 90 and 50 miles east of Interstate 35. U.S. Highway 52 connects Rochester to Minneapolis and St. Paul, which are approximately 80 miles to the northwest. U.S. Highways 14 and 63 also intersect in Rochester.

Traveling by air
Things to remember before booking:
• Several cities in the United States are named Rochester. Mayo Clinic is in Rochester, Minnesota, airport code RST.

Rochester International Airport
American Airlines has daily, nonstop jetliner service to and from Rochester via American Airlines’ hub at O’Hare International Airport (ORD) in Chicago.

Delta Airlines serves Rochester from its hub at Minneapolis–St. Paul International Airport (MSP). Daily, non-stop jetliner service to and from Rochester is available. Delta also offers one daily flight to and from Detroit at the Rochester airport.

Minneapolis–St. Paul International Airport
Minneapolis–St. Paul International Airport is located 80 miles north of Rochester and is a major hub with regularly scheduled service provided by most airlines. Connecting flights to Rochester International Airport or ground transportation to Rochester is available.


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