Cardiac amyloidosis is an important cause of restrictive cardiomyopathy and is not as rare as previously reported. Transthyretin cardiac amyloidosis is an under-recognized cause of heart failure in middle-aged and elderly men and in blacks. Treatment is now available for all types of cardiac amyloidosis and is rapidly evolving. Delayed diagnosis continues to be a major determinant of poor prognosis. This tutorial will review the three most types of amyloid that involve the heart. The state-of-the art approach to diagnosis and management of cardiac amyloidosis will be discussed.